Diindolylmethane (DIM) is a compound derived from cruciferous vegetables like broccoli, cauliflower, and cabbage. Its mechanism of action involves modulating estrogen metabolism in the body. DIM promotes the conversion of estrogen into its beneficial metabolites, such as 2-hydroxyestrone, while reducing the production of potentially harmful metabolites like 16-alpha-hydroxyestrone. By balancing estrogen metabolism, DIM helps maintain hormone levels in equilibrium, which is particularly beneficial for women. DIM is known for its ability to support estrogen balance, potentially reducing the risk of estrogen-related conditions such as breast and uterine cancers. Additionally, DIM may alleviate symptoms of estrogen dominance, including bloating, breast tenderness, and mood swings. As a dietary supplement, DIM offers a natural approach to promoting hormonal health and overall well-being.

Applications: Estrogen metabolism support, estrogen dominance

Dosage: 100-200mg

Recommended Source: Diindolylmethane

Overconsumption: Gastrointestinal discomfort, headaches

Contraindications: Pregnancy and breastfeeding, thyroid disorders

Vitex also known as Chaste Tree Berry, is a herbal remedy derived from the fruit of the Vitex agnus-castus tree. Its mechanism of action involves influencing the hypothalamic-pituitary-ovarian (HPO) axis, which regulates hormone production in the body. Vitex contains compounds that interact with dopamine receptors, leading to changes in the secretion of prolactin and luteinizing hormone (LH). As a result, it helps to balance estrogen and progesterone levels in women. Vitex is commonly used to alleviate symptoms associated with menstrual irregularities, premenstrual syndrome (PMS), and menopause. Its benefits include regulating menstrual cycles, reducing breast tenderness, alleviating mood swings, and easing symptoms of menopause such as hot flashes and night sweats.

Applications: Premenstrual syndrome (PMS), Regulating menstrual cycles, Supporting fertility and reproductive health

Dosage: 20-40mg

Recommended Source: Vitex

Overconsumption: Gastrointestinal upset, hormonal imbalances

Contraindications: Pregnancy and breastfeeding, hormone-sensitive conditions

Tongkat Ali also known as Eurycoma longifolia, is a herbal supplement native to Southeast Asia with a long history of traditional use for its purported health benefits. It is believed to act as an adaptogen, helping the body adapt to stress and supporting overall well-being. Tongkat Ali's mechanism of action involves its active compounds, particularly quassinoids, which may influence various physiological processes, including hormone regulation and energy metabolism. The herb is commonly associated with potential benefits for hormonal balance, particularly in men, by promoting testosterone production. This hormonal support may contribute to improved libido, muscle mass, and energy levels. Additionally, Tongkat Ali is believed to possess antioxidant properties, aiding in cellular protection against oxidative stress. However, the scientific evidence supporting its efficacy in testosterone enhancement is still limited and inconclusive. Some believe it may act like a SERM such as Clomiphene, blocking estrogen receptors in the hypothalamus to stimulate the production of LH & FSH. While Tongkat Ali is generally considered safe for short-term experimental use, long-term effects and safety remain unclear.

Applications: Enhances testosterone levels, boosts libido

Dosage: 400mg

Recommended Source: Tongkat Ali

Overconsumption: Hormonal imbalance, liver toxicity

Contraindications: Hormone-sensitive conditions, liver disease

Fadogia Agrestis is a plant known for its traditional use in African herbal medicine, particularly for its potential effects on testosterone levels. Some studies suggest that Fadogia agrestis may have properties that could positively influence testosterone production. However, research on its efficacy and safety, especially in human subjects, remains limited and inconclusive. It's postulated that it may increase intratesticular cholesterol levels and lead to Leydig cell stimulation, however there are also concerns over testicular toxicity. Further scientific investigation is needed to better understand its mechanisms of action and potential benefits for testosterone regulation.

Applications: Traditional aphrodisiac, male hormones & fertility

Dosage: 600mg

Recommended Source: Fadogia Agrestis

Overconsumption: Hormonal imbalance, testicular toxicity

Contraindications: Hormone-sensitive conditions, liver disease